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Before & After
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How parentheses appear...

As you age, your skin changes. For example, it reduces production of a naturally hydrating substance called hyaluronic acid (HA). Over time, the loss of HA in your skin results in facial wrinkles and folds, like those "parentheses" lines around your mouth.

...and disappear

JUVEDERM® injectable gel replaces the HA your skin has lost, bringing back its volume and smoothing away facial wrinkles and folds. A breakthrough in HA dermal fillers, JUVEDERM® is the first smooth consistency HA gel and the any HA filler that's FDA approved to last up to a year. Everyone will notice, but no one will know You can experience the benefits of JUVEDERM® injectable gel in a quick, in-office procedure. Your healthcare professional eases JUVEDERM® under your skin to instantly smooth out the wrinkles and folds on your face. You'II see the difference immediately!

What makes JUVEDERM® different?

While ether HA fillers en the market have a mere granular censistency, JUVEDERM® injectable gel is the first smooth consistency I-lA gel. This is due te an innevative manufacturing process called HYLACROSS™ technology. HYLACROSS™ gives JUVEDERM® its unique smooth—gel properties as well as an optimal gel structure that holds up over time. That's why JUVEDERM® injectable gel is the only I—lA filler that's FDA approved to last up to 1 year.*

High patient preference

When JUVEDERM® was tested in a clinical setting ameng peeple whe didn't knew which filler they were getting, nearly 90% stated a preference fer JUVEDERM®! In addition, JUVEDERM® injectable gel has been tested en all skin phetetypes, both male and female, se everyone can enjoy the benefits of JUVEDERM®. Are you ready to smooth out your parentheses or other facial wrinkles and folds? Ask your healthcare professional about JUVEDERM® injectable gel.

What makes JUVEDERM® different?

While ether HA fillers en the market have a mere granular censistency, JUVEDERM® injectable gel is the first smeethgcensistency I-lA gel. This is due te an innevative manufacturing precess called HYLACROSS™ technology. HYLACROSS™ gives JUVEDERM® its unique smeeth—gel preperties as well as an eptimal gel structure that helds up ever time. That's why JUVEDERM® injectable gel is the enly I—lA fillerthat's FDA approved to last up to 1 year.* High patient preference

When JUVEDERM® was tested in a clinical setting ameng peeple whe didn't knew which filler they were getting, nearly 90% stated a preference fer JUVEDERM®!l In additien, JUVEDERM® injectable gel has been tested en all skin phetetypes, beth male and female, se everyene can enjey the benefits of JUVEDERM®. Are yeu ready te smooth out yeur parentheses er ether facial wrinkles and felds? Ask yeur healthcare prefossional about JUVEDERM® injectable gel.

What you can expect during and alter JUVEDERM® injectable gel treatment?

Wrinkle correction with JUVEDERM® is a quick, in-office procedure with immediate results and minimal downtime. Common side effects with JUVEDERM® injectable gel usually are mild or moderate. Ask your healthcare professional how to manage them.

[Before and After Image]

A Brief Description of Relevant Indications for Use, Contraindications, Warnings, Precautions, and Adverse Events for JUVEDERM® injectable Gel

Indication: In the United States, JUVEDERM® injectable gel is indicated for correction of moderate to severe facial wrinkles and folds (such as nasolabial folds).

Contraindications: JUVEDERM® injectable gel should not be used in patients who have severe allergies marked by a history of anaphylaxis or history or presence of multiple severe allergies. JUVEDERM® injectable gel should not be used in patients with a history of allergies to Gram-positive bacterial proteins.

Warnings: JUVEDERM® injectable gel should not be injected into blood vessels. lf there is an active inflammatory process or infection at specific injection sites, treatment should be deferred until the underlying process is controlled.

Precautions: The safety of JUVEDERM® injectable gel for use during pregnancy, in breastfeeding females, or in patients under 18 years has not been established. The safety and effectiveness of JUVEDERM® injectable gel for the treatment of areas other than facial wrinkles and folds (such as lips) have not been established in controlled clinical studies. Patients who are using substances that can prolong bleeding, such as aspirin or ibuprofen, as with any injection, may experience increased bruising or bleeding at injection site. Patients should inform their physician before treatment if they are using these types of substances. As with all skin—injection procedures, there is a risk of infection. JUVEDERM® injectable gel should be used with caution in patients on immunosuppressive therapy, or therapy used to decrease the body's immune response, as there may be an increased risk of infection. The safety of JUVEDERM® injectable gel in patients with a history of excessive scarring (eg, hypertrophic scarring and keloid formations) and pigmentation disorders has not been studied. If laser treatment, chemical peel, or any other procedure based on active dermal response is considered after treatment with JUVEDERM® injectable gel, or if JUVEDERM® injectable gel is administered before the skin has healed completely after such a procedure, there is a possible risk of an inflammatory reaction at the treatment site.

Adverse events:The most commonly reported side effects are temporary injection-site redness, swelling, pain/tenderness, firmness, lumps/bumps, and bruising. ll/lost side effects are mild or moderate in nature, and their duration is short lasting (7 days or less).

Important: For full safety information, please visit www.juvederm.com or call Allergan Product Support at 1-877-345-5372.

CAUTION: This device is restricted to sale by or on the order of a physician.

 

BOTOX® Cosmetic (Botulinum Toxin Type A)

BOTOX® Cosmetic is approved for the temporary treatment of moderate to severe frown lines between the brows in people ages 18 to 65.

 

Important Safety Information Serious heart .problems and serious allergic reactions have been reported rarely. lf you think you are having an allergic reaction or other reactions, such as difficulty swallowing, speaking, or breathing, call your doctor immediately. The most common side effects following injection include temporary eyelid droop and nausea. Localized pain, infection, inflammation, tenderness, swelling, redness, and/or bleeding/bruising may be associated with the injection. Patients with certain neuromuscular disorders such as ALS, myasthenia gravis, or Lambert-Eaton syndrome may be at increased risk of serious side effects.

Full prescribing information has been provided to your doctor. www. botoxcosmetic.com 1-800—BOTOXMD